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Seattle Mariners at Houston Astros
| Time | Location | Television | Previews |
| 5:10 pm PDT | Minute Maid Park | ROOT Sports | Game | Series |
"OK, we won a game yesterday. If we win today, it's called two in a row. And if we win again tomorrow, it's called a winning streak. It has happened before."
| Seattle | Houston |
| 8 Endy Chavez | 4 Jose Altuve |
| 5 Kyle Seager | DH Fernando Martinez |
| DH Kendrys Morales | 2 Jason Castro |
| 9 Michael Morse | 7 Chris Carter |
| 3 Justin Smoak | 3 Carlos Pena |
| 7 Raul Ibanez | 8 Justin Maxwell |
| 2 Jesus Montero | 9 Rick Ankiel |
| 4 Dustin Ackley | 5 Matt Dominguez |
| 6 Brendan Ryan | 6 Marwin Gonzalez |
| 1 Hisashi Iwakuma | 1 Bud Norris |